0000001614 00000 n

... Statin Dose Comparison. 0000025475 00000 n 0000015793 00000 n

0000011338 00000 n 0000052631 00000 n 0000038405 00000 n 0000028082 00000 n 0000004582 00000 n 0000028819 00000 n 0000020206 00000 n 0000001790 00000 n Resource #320703. 0000030607 00000 n April 2018. ph-genantidepflr-03-19. 0000052895 00000 n

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If the CK level obtained in a symptomatic patient is <10 × ULN but muscle symptoms are tolerable, statin therapy can be continued with or without a dose reduction and symptoms can be used as a clinical guide to stop or continue statin therapy from that point forward. 0000004058 00000 n 0000007210 00000 n Pharmacist’s Letter/Prescriber’s Letter. trailer < 0000004582 00000 n 0000032489 00000 n 0000009086 00000 n 0000045878 00000 n Another barrier to the reporting of statin-associated myopathy is the lack of a consensual definition and diagnostic criteria. September 2018. 0000032489 00000 n All rights reserved. However, statin-associated myopathy affects up to 10% of patients receiving statin therapy.Pharmacists in the inpatient and outpatient setting may be directly involved in the monitoring of medication therapy and tolerability, and therefore should be aware of the signs and symptoms of statin-associated myopathy.

April 2018. ph-genantidepflr-03-19. 0000028082 00000 n

0000045607 00000 n 0000030607 00000 n 0000004200 00000 n Pharmacist’s Letter/Prescriber’s Letter. 0000052631 00000 n 0000055412 00000 n 0000033161 00000 n 0000004058 00000 n medical chart clipart weather chart clipart preschool job chart clip art chore chart clip art job chart clip art. The National Lipid Association (NLA) defines myopathy as symptoms of myalgia in addition to an elevation in serum creatine kinase (CK) greater than 10 times the upper limit of normal (CK >10 × ULN). 0000038128 00000 n

0000038871 00000 n As a class, statins and their related combination products generated $16.9 billion in u.S. sales in 2012. One proposed mechanism suggests that decreased cholesterol concentrations secondary to statin therapy may result in alterations in myocyte membrane cholesterol.

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%PDF-1.4 %���� 152 52 Monitoring is important at the time of initiation, as baseline elevations in CK levels are not uncommon and the knowledge of this prior to starting statin therapy may be helpful should a patient develop muscle symptoms while on statin therapy.Neither the ACC/AHA/NHLBI nor the NLA recommends routine CK level monitoring in all patients after beginning statin therapy, but instead recommends obtaining CK level only in patients who develop muscle symptoms while on statin therapy.Alternatively, according to the NLA, statin therapy should be discontinued in patients who develop intolerable muscle symptoms regardless of CK level. Impaired renal or …

0000024360 00000 n 0000000016 00000 n 0000007579 00000 n 0000028421 00000 n 0000045878 00000 n Proper assessment of patients will assist in the recognition of patients at risk. The American College of Cardiology (ACC), American Heart Association (AHA), and National Heart, Lung, and Blood Institute (NHLBI) use myopathy as a general term referring to any disease of the muscles, which is the most common definition.When compared to clinical practice, the number of patients reporting statin-associated myopathy during clinical trials remains low, primarily because patients who are susceptible to, or who have an increased risk for, statin-associated adverse events are often excluded from clinical trials. May 2012 (full update Nov 2013).

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