Therefore, caution should be taken when using fluoroquinolones, including ofloxacin, in these populations. Caution should be exercised when ofloxacin is coadministered with drugs that affect the tubular renal secretion such as probenecid, cimetidine, furosemide and methotrexate.Ofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong the QT interval (e.g. In the chronic carriers ofloxacin was used in a dose of 400 mg twice a day for 5 days. When suggestions are available use up and down arrows to review and ENTER to select. warfarin), coagulation tests should be monitored when these drugs are given concomitantly (see section 4.5).Fluoroquinolones, including ofloxacin, have neuromuscular blocking activity and may exacerbate muscle weakness in patients with myasthenia gravis.
The dosage range for adults is 200 mg to 800 mg daily. The phototoxic, photomutagenic and photocarcinogenic potential of ofloxacin is comparable with that of other gyrase inhibitors. CrCl 20-50 mL/min: Give q24hr; CrCl ; 20 mL/min: Give one-half usual dose q24hr Other Indications and Uses The plasma half-life is prolonged in persons with renal insufficiency; total and renal clearance decrease in accordance with the creatinine clearance. 400 mg orally every 12 hours for 10 days. Rechelist Pharma ( Biophar Lifesciences Private Limited) - Offering
The drug was used in a dose of 200 mg twice a day for 5 days. Important Information. Dosage Modifications Renal impairment. The plasma elimination half-life was 5.7 to 7.0 hours and was not dose related. In renal insufficiency the dose should be reduced. Excretion is primarily renal. If tendinitis is suspected, treatment with ofloxacin must be halted immediately, and appropriate treatment (e.g. It has an osmolality of 300 mOsm/kg. The dose of ofloxacin is determined by the type and severity of the infection. In this case, it is preferable to administer ofloxacin in the morning.Daily doses of more than 400 mg must be divided into two separate doses and be given at approximately equal intervals.Ofloxacin tablets should be swallowed whole with sufficient liquid before or during meal times. Inoflox® Tablet and Solution Prescription Drug.
treatment for shock) should be initiated.Diarrhoea, especially if severe, persistent and/or bloody, occurring during or after treatment with ofloxacin (including several weeks after treatment), may indicate a condition caused by Appropriate specific antibiotic therapy must be started without delay (e.g. 200 mg PO q12hr for 10 days. They should not be taken within two hours of mineral antacids, sucralfate or metal ion preparations (aluminium, iron, magnesium or zinc), didanosine chewable or buffered tablets (for HIV), since reduction of absorption of ofloxacin can occur (see section 4.5).The use of ofloxacin is contraindicated as follows: Achilles tendon) which may occur within 48 hours of treatment start and may be bilateralGeneral disorders and administration site conditionsPain (including pain in back, chest and extremities)Reporting suspected adverse reactions after authorisation of the medicinal product is important. It is recommended that patients should not expose themselves unnecessarily to strong sunlight or to artificial UV rays (e.g. The dose of ofloxacin is determined by the type and severity of the infection. Ofloxacin 200 mg Film-coated Tablets only: The tablet can be divided into equal doses.
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