This big clinical trial or those large observational studies?" Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. The researchers found that combined hormone replacement therapy (HRT) -- with estrogen and progestin -- … Meanwhile, the reduced risk seen with estrogen-only therapy also continued. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

New Study Shakes Up Thinking on Hormone Replacement TherapyFRIDAY, Dec. 13, 2019 (HealthDay News) -- The ongoing debate about postmenopausal hormone therapy and breast cancer risk may have turned even more muddy: A large, new study suggests that two different types of hormone therapy have opposite effects on women's long-term risk of the disease.The researchers found that combined hormone replacement therapy (HRT) -- with estrogen and progestin -- increases the risk of breast cancer, with effects that last for years after women discontinue the therapy.On the other hand, women who take estrogen alone appear to have an equally long-lasting decrease in their breast cancer risk.The findings come from a long-term follow-up of the Women's Health Initiative (WHI) -- a major U.S. government-funded project begun in the 1990s that tested the health effects of hormone replacement therapy.
asked Dr. Rowan Chlebowski, the lead researcher on the new analysis.Unfortunately, there is no clear answer, according to Chlebowski, chief of medical oncology at Harbor-UCLA Medical Center, in Los Angeles.He is to present the findings Friday at the annual San Antonio Breast Cancer Symposium.

A number of observational studies -- which followed women in the "real world" who opted for hormone therapy or not -- have found that estrogen-only therapy Enter these latest findings from the WHI.

The most common presentation of menopause (60% of postmenopausal women) is hypothalamically mediated vasomotor instability leading to hot flashes (hot flushes), sweating, and palpitations. If you already have heart disease or you have a history of blood clots, the risks of hormone therapy have been clearly shown to outweigh any potential benefits.Talk with your doctor about these strategies to reduce the risks of menopause hormone therapy:Women of all ages should take heart disease seriously.

"We're encouraged to see the results of research like this. Consider these points:Menopause hormone therapy risks may vary depending on:If you've already had a heart attack, menopause hormone therapy is not for you. Other common presenting symptoms include the following: 1. Hormone replacement therapy was standard treatment to relieve hot flashes, vaginal dryness, insomnia and other menopausal symptoms.

Given the overall body of evidence, experts have long advised women against using hormone therapy to prevent any disease. "Overall," Chlebowski said, "this information suggests that combined HRT is a little worse than we'd thought, and estrogen alone is probably a little safer than we'd thought.
A deadly attack in Pensacola, Florida, last year and another earlier this week in Somalia show the ongoing dangers of the terrorist group on which America set its sights 19 years ago. "Large population studies are needed to understand the complex impact menopausal hormone therapy has on breast cancer risk and incidence," Brown said. They show that for years after stopping combined HRT, women continue to face an increased risk of breast cancer. The spectrum and intensity of perimenopausal and menopausal symptoms vary greatly due to the effect of decreased circulating levels of estrogen on various organ systems. But estrogen therapy may help if you either can't tolerate or aren't benefiting from other treatments.

"If your menopausal hot flashes are bad enough that you want to try hormone therapy, talk with your doctor about the benefits and risks to you. "Susan Brown is senior director of education and patient support at the nonprofit Susan G. Komen. The new findings give women another piece of information "to make informed decisions about their health," she agreed.

The largest randomized, controlled trial to date actually found a small increase in heart disease in postmenopausal women using combined (both estrogen and progestin) hormone therapy. As recently as 10 years ago, virtually every woman at menopause automatically got a prescription for estrogen or estrogen combined with progestin, another female hormone. Dec. 13, 2019. Hormone replacement therapy was also thought to reduce the risk of heart disease.Before menopause, women have a lower risk of heart disease than men do. "So, who's right? Learn more >> "Trial participants on combined HRT typically used it for about five years. For women in this study using estrogen alone, there was no increased risk in heart disease.Other studies suggest that hormone therapy, especially estrogen alone, may not affect — or may even decrease — the risk of heart disease when taken early in postmenopausal years. "You should not use hormone therapy to lower chronic disease risks," he said. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. The other involved close to 11,000 women the same age who were given either estrogen therapy alone or placebos.Before the WHI, doctors had thought that menopausal hormone therapy -- which helps control hot flashes -- had other health benefits, including a lower risk of heart disease.But the initial findings from the WHI made waves when they instead uncovered higher disease risks: Combined HRT raised women's odds of developing heart disease, stroke, blood clots and breast cancer.The picture was different with estrogen-only therapy: It raised the risk of blood clots and stroke, but did not increase heart risks. Hormone replacement therapy (HRT) is designed to help with those.

Understand potential risks to your heart and whether hormone therapy is right for you.Long-term hormone replacement therapy used to be routinely prescribed for postmenopausal women to relieve hot flashes and other menopause symptoms.

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