There was no significant difference between these groups in the likelihood of a switch to oral diuretics at 48 hours (22% in the bolus group and 26% in the continuous-infusion group, P=0.44).Patients' Global Assessment of Symptoms during the 72-Hour Study-Treatment Period.Secondary End Points for Each Treatment Comparison.There was also no significant between-group difference in the primary safety end point of the change in serum creatinine level from baseline to 72 hoursThere were also no significant between-group differences across a variety of secondary end pointsPatients assigned to the high-dose strategy were more likely to change to oral diuretics at 48 hours than were those assigned to the low-dose strategy (31% vs. 17%, P<0.001).

Sep 2, 2020

128. LeFevre M. ACC/AHA hypertension guideline: what is new?

A randomized trial of intensive versus standard blood-pressure control. This document aims to provide clear guidance to healthcare professionals regarding the Gupta D, Georgiopoulou VV, Kalogeropoulos AP et al.


134. Yancy CW. Effect of diuresis on the performance of the failing left ventricle in man.

Kernan WN, Ovbiagele B, Black HR et al.

130. Tuck S, Morselli P, Broquaire M et al. Mirochnick MH, Miceli JJ, Kramer PA et al.

Prevention, detection, evaluation, and management of high blood pressure in adults: synopsis of the 2017 American College of Cardiology/American Heart Association hypertension guideline. Initially 20–50 mg, then (by intramuscular injection or by intravenous injection or by intravenous infusion) increased in steps of 20 mg every 2 hours if required, doses greater than 50 mg given by intravenous infusion only; maximum 1.5 g per day. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. 1224. Torres-Courchoud I, Chen HH.

for the TONE Collaborative Research Group. Qaseem A, Wilt TJ, Rich R et al.

Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). 140. Carey RM, Whelton PK, 2017 ACC/AHA Hypertension Guideline Writing Committee. James PA, Oparil S, Carter BL et al. Prevention, detection, evaluation, and management of high blood pressure in adults.

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Pathogenesis and management of edema in the newborn.

4 hours) is to be preferred to a regimen with higher bolus doses at longer intervals. To convert the values for creatinine to micromoles per liter, multiply by 88.4.Kaplan–Meier curves are shown for death, rehospitalization, or emergency department visit during the 60-day follow-up period in the group that received boluses every 12 hours as compared with the group that received a continuous infusion (Panel A) and in the group that received a low dose of the diuretic (equivalent to the patients' previous oral dose) as compared with the group that received a high dose (2.5 times the previous oral dose) (Panel B).Tap into groundbreaking research and clinically relevant insights

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